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Exposure to antiepileptic drugs continues through lactation, although to a lesser degree Combined with the potential bene ts, the potential risks lead to considerable controversy over the practice of breastfeeding by mothers on these medications (Pennell et al, 2007) Common characteristics of fetal anticonvulsant syndromes include congenital malformation, distinct facial features, myopia, joint laxity, and other minor anomalies (J Dean et al, 2007) Animal studies consistently indicate the potential for multiple teratogenic effects of anticonvulsant drugs (Meador, 2002b) While most of the research has been retrospective, the establishment of various pregnancy registries and follow-up procedures have added to a growing prospective knowledge base Exposure effects have been identi ed for various medications; however, in general, the continued use of phenytoin (Dilantin) and lamotrogine (Lamictal) is less often associated with major birth defects (J Dean et al, 2002; Eberhard-Gran, Eskild, & Opjordsmoen, 2006).

The seriousness of the defects identi ed during code reviews should be assessed, and severe defects should be reported in the problem tracking system and used in defect analysis and prevention.

where b is the slope of S on the log plot,

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Of the antiepileptic drugs, sodium valproate (Depakote) often is prescribed due to its broad anticonvulsant action as well as its less sedative and behavioral side effects as compared to other antiepileptic drugs (Carrion et al, 2007) For example, of 414 children exposed to lamotrogine alone and 182 exposed to lamotrogine and some other antiepileptic other than valproate, major birth defects occurred in 29% and 27% respectively (Cunningham, Tennis, & International Lamotrigine Pregnancy Registry Scienti c Advisory Committee, 2005) In contrast, for the 88 children who were exposed to lamotrogine and valproate, the incidence of major birth defects increased to 125% (Cunningham et al, 2005) Notably, a majority of major malformations are identi ed within the rst ve days after birth, particularly with valproate exposure (Meador et al, 2006; Wyszynski et al, 2005) Carbamazepine (Tegretol) is another antiepileptic medication.

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This type of differential protection is biased for reasons that will be explained later on. It is activated when the differential current reaches a certain percentage of the through current.

In utero exposure to carbamazepine monotherapy was not associated with decreased cognitive function (Wide, Henning, Tomson, & Winbladh, 2002)..

To conclude this section on descriptors, the following discussion concentrates on some of the trickier areas of descriptor manipulation.

In Equations (4.14a) and (4.14b), (xi, yi) is the current point, (xi+1, yi+1) is its forward point, and (xi 1, yi 1) is its backward point. It is assumed that the intervals in

McNemar, Q., 4, 284 Mead, R., 98, 292 Mebane, W. Jr., 101, 296 Mees, A., 102, 288 Megiddo, N., 31, 281 Mehta, C. R., 250, 281 Meier, K. J., 111, 290, 297 Mendell, N. R., 40, 86 87, 88, 276 Mengersen, K. L., 125, 290 Metropolis, N., 4, 100, 126, 127, 290 Meyer, C. D., Jr., 154, 271 Meyn, S. P., 122 125, 264, 274, 290 Michalewicz, Z., 100, 102, 103, 290 Micheas, A., 73, 274 Mihram, D., 139, 290 Mihram, G. A., 139, 290 Miller, D. J., 83, 97, 283, 290 Miller, J. W., 33, 287 Miller, K. W., 33, 132, 138, 293 Miller, W. E., 255, 290 Mitra, S. K., 174, 294 Mittelhammer, R. C., 97, 290 Mittelmann, H. D., 100, 290 Moghrabi, I. A., 97, 277 Moller, J., 264, 284 Monahan, J. F., 140, 290 Mongeau, M., 102, 103, 290 Montgomery, D. C., 21, 104, 290, 291 Mooney, C. Z., 5, 290 Moore, D. S., xiv, 290, 291 Moore, E. H., 152 153, 291 Moore, J., 22, 272 Moore, L. R., 130, 276 Mor , J. J., 52, 100, 291 e Moreno, E., 73, 283, 291 Morgan, B. J. T., 130, 291 Morgan, J. T., 107, 270 Morris, C., 174, 275 Morwitz, V. G., 140, 301 Moshier, S. L., 59, 92, 291 Mosteller, F., 72, 275, 281 Moulton, B. R., 73, 301 Mroz, T. A., 202, 291 Mukhopadhyay, P., 78, 291 M ller, M. E., 136, 270 u Murray, G. P., 156, 276 Murray, W., 73, 76, 84, 85, 156 157, 185, 202, 211, 278 Myers, R. H., 104, 291

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