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Above the system heap is a partition of memory for loading programs. When a program is loaded, it s allocated a chunk of memory from the application partition based on the application s SIZE resource. On the Macintosh, a resource holds a specific piece of information for an application. (Resources are discussed in more detail in section C.3.7.) The SIZE resource tells the operating system the program s preferred and minimum memory requirements. Each application partition is divided into segments that contain items such as the program heap, stack, and global variables. On the Macintosh (68k architecture), stacks grow toward low memory and heaps grow toward high memory. As with other operating systems, the heap is used mainly for allocating memory. As a program runs, it typically allocates and deallocates memory from its application heap. Over time, the application s heap can become fragmented, meaning that unused memory areas are not contiguous; therefore memory requests that exceed the size of the largest unused memory area will be rejected, even though cumulatively enough free memory exists. To address this issue, the Memory Manager performs periodic heap compaction and purging in an attempt to relocate smaller chunks of memory into contiguous blocks. As you can imagine, moving memory within the heap at runtime can wreak havoc on application programs that rely on the addresses of allocated memory. Under Mac OS, these semantics are implemented using handles and pointers. Handles can be moved, but pointers are stuck and cannot be compacted. A handle is a pointer into a master pointer block that holds pointers to allocated memory. These pointers can move during heap compaction, which results in stale pointers. The handle stays valid, even though the pointer it points to has changed. You can
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Tinea versicolor is a mild, superficial Malassezia furfur infection of the skin (usually of the upper trunk) This yeast is a colonizer of all humans, which accounts for the high recurrence rate after treatment The eruption is often called to patients attention by the fact that the involved areas will not tan, and the resulting hypopigmentation may be mistaken for vitiligo A hyperpigmented form is not uncommon
1 Macerated stage Treat with aluminum subacetate solution soaks for 20 minutes twice daily Broad-spectrum antifungal creams and solutions (containing imidazoles or ciclopirox instead of tolnaftate and haloprogin) will help com-
Lesions are asymptomatic, but a few patients note itching The lesions are velvety, tan, pink, or white macules that
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vary from 4 5 mm in diameter to large confluent areas The lesions initially do not look scaly, but scales may be readily obtained by scraping the area Lesions may appear on the trunk, upper arms, neck, and groin
Two forms of chronic cutaneous lupus erythematosus (CCLE) occur: chronic scarring (discoid) lesions (DLE) and erythematous non-scarring red plaques (subacute cutaneous LE) (SCLE) Both occur most frequently in areas exposed to solar irradiation Permanent hair loss and loss of pigmentation are common sequelae of discoid lesions Systemic lupus erythematosus (SLE) is discussed in 20 Patients with SLE may have DLE or SCLE lesions
Large, blunt hyphae and thick-walled budding spores ( spaghetti and meatballs ) are seen on KOH Fungal culture is not useful
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Vitiligo usually presents with larger periorificial lesions Vitiligo (and not tinea versicolor) is characterized by total depigmentation, not just a lessening of pigmentation Vitiligo does not scale Pink and red-brown lesions on the chest are differentiated from seborrheic dermatitis of the same areas by the KOH preparation
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Symptoms are usually mild The lesions consist of dusky red, well-localized, single or multiple plaques, 5 20 mm in diameter, usually on the face The scalp, external ears, and oral mucous membranes may be involved In discoid lesions there is atrophy, telangiectasia, depigmentation, and follicular plugging Discoid lesions may be covered by dry, horny, adherent scales On the scalp, significant hair loss may occur
Topical treatments include selenium sulfide lotion, which may be applied from neck to waist daily and left on for 5 15 minutes for 7 days; this treatment is repeated weekly for a month and then monthly for maintenance Ketoconazole shampoo, 1% or 2%, lathered on the chest and back and left on for 5 minutes may also be used weekly for treatment and to prevent recurrence Clinicians must stress to the patient that the raised and scaly aspects of the rash are being treated; the alterations in pigmentation may take months to fade or fill in Ketoconazole, 200 mg daily orally for 1 week or 400 mg as a single oral dose, results in short-term cure of 90% of cases Patients should be instructed not to shower for 8 12 hours after taking ketoconazole, because it is delivered in sweat to the skin The single dose may not work in more hot and humid areas, and more protracted therapy carries a small but finite risk of drug-induced hepatitis Without maintenance therapy, recurrences will occur in over 80% of cured cases over the subsequent 2 years Newer imidazole creams, solutions, and lotions are quite effective for localized areas but are too expensive for use over large areas such as the chest and back
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