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ical discomfort, daytime napping, and early bedtimes are common factors Psychiatric disorders are often associated with persistent insomnia Depression is usually associated with fragmented sleep, decreased total sleep time, earlier onset of REM sleep, a shift of REM activity to the first half of the night, and a loss of slow wave sleep all of which are nonspecific findings In manic disorders, sleeplessness is a cardinal feature and an important early sign of impending mania in bipolar cases Total sleep time is decreased, with shortened REM latency and increased REM activity Sleep-related panic attacks occur in the transition from stage 2 to stage 3 sleep in some patients with a longer REM latency in the sleep pattern preceding the attacks Abuse of alcohol may cause or be secondary to the sleep disturbance There is a tendency to use alcohol as a means of getting to sleep without realizing that it disrupts the normal sleep cycle Acute alcohol intake produces a decreased sleep latency with reduced REM sleep during the first half of the night REM sleep is increased in the second half of the night, with an increase in total amount of slow wave sleep (stages 3 and 4) Vivid dreams and frequent awakenings are common Chronic alcohol abuse increases stage 1 and decreases REM sleep (most drugs delay or block REM sleep), with symptoms persisting for many months after the individual has stopped drinking Acute alcohol or other sedative withdrawal causes delayed onset of sleep and REM rebound with intermittent awakening during the night Heavy smoking (more than a pack a day) causes difficulty falling asleep apparently independently of the often associated increase in coffee drinking Excess intake near bedtime of caffeine, cocaine, and other stimulants (eg, over-the-counter cold remedies) causes decreased total sleep time mostly NREM sleep with some increased sleep latency Sedative-hypnotics specifically, the benzodiazepines, which are the most commonly prescribed drugs to promote sleep tend to increase total sleep time, decrease sleep latency, and decrease nocturnal awakening, with variable effects on NREM sleep Withdrawal causes just the opposite effects and results in continued use of the drug for the purpose of preventing withdrawal symptoms Antidepressants decrease REM sleep (with marked rebound on withdrawal in the form of nightmares) and have varying effects on NREM sleep The effect on REM sleep correlates with reports that REM sleep deprivation produces improvement in some depressions Persistent insomnias are also related to a wide variety of medical conditions, particularly delirium, pain, respiratory distress syndromes, uremia, asthma, and thyroid disorders Adequate analgesia and proper treatment of medical disorders will reduce symptoms and decrease the need for sedatives.

Total Daily Dose 800 1200 mg (IV), 05 15 g (PO) 320 mg PO 250 750 mg (PO/IV) 400 mg (PO) 400 800 mg (PO/IV)

This means that myOtherVariable is now equal to the value in myVariable, which is 15. Remember that in assignment, it s the variable on the left that gets the assigned value. The assignment operator also allows you to chain assignments, assigning the same value to multiple variables, as follows:

In the Macintosh world, programs are user driven. In a program s main event loop, it calls the WaitNextEvent function, which waits for an event to happen and switches cooperatively to other applications. This is done transparently to the running application.

Table 30 9 Examples of initial antimicrobial therapy for acutely ill, hospitalized adults pending identification of causative organism

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