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some women Cognitive impairments are common Health care utilization for a variety of health problems is increased in chronic marijuana smokers Sudden withdrawal produces insomnia, nausea, myalgia, and irritability Psychological effects of chronic marijuana usage are still unclear Urine testing is reliable if samples are carefully collected and tested Detection periods span 4 6 days in acute users and 20 50 days in chronic users

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Stimulant abuse is quite common, either alone or in combination with abuse of other drugs The amphetamines, including Methedrine ( speed ) one variant is a smokable form called ice, which gives an intense and fairly long-lasting high methylphenidate, and phenmetrazine, are under prescription control, but street availability remains high Moderate usage of any of the stimulants produces hyperactivity, a sense of enhanced physical and mental capacity, and sympathomimetic effects The clinical picture of acute stimulant intoxication includes sweating, tachycardia, elevated blood pressure, mydriasis, hyperactivity, and an acute brain syndrome with confusion and disorientation Tolerance develops quickly, and, as the dosage is increased, hypervigilance, paranoid ideation (with delusions of parasitosis), stereotypy, bruxism, tactile hallucinations of insect infestation, and full-blown psychoses occur, often with persecutory ideation and aggressive responses Stimulant withdrawal is characterized by depression with symptoms of hyperphagia and hypersomnia People who have used stimulants chronically (eg, anorexigenics) occasionally become sensitized ( kindling ) to future use of stimulants In these individuals, even small amounts of mild stimulants such as caffeine can cause symptoms of paranoia and auditory hallucinations Cocaine is a stimulant It is a product of the coca plant The derivatives include seeds, leaves, coca paste, cocaine hydrochloride, and the free base of cocaine Cocaine hydrochloride is the salt and the most commonly used form Free base, a purer (and stronger) derivative called crack, is prepared by simple extraction from cocaine hydrochloride There are various modes of use Coca leaf chewing involves toasting the leaves and chewing with alkaline material (eg, the ash of other burned leaves) to enhance buccal absorption One achieves a mild high, with onset in 5 10 minutes and lasting for about an hour Intranasal use is simply snorting cocaine through a straw Absorption is slowed somewhat by vasoconstriction (which may eventually cause tissue necrosis and septal perforation); the onset of action is in 2 3 minutes, with a moderate high (euphoria, excitement, increased energy) lasting about 30 minutes The purity of the cocaine is a major determinant of the high Intravenous use of cocaine hydrochloride or freebase is effective in 30 seconds and produces a short-lasting, fairly intense high of about 15 minutes duration The combined use of cocaine and ethanol results in the metabolic production of cocaethylene by the liver This substance produces more intense and long-lasting cocaine-like effects Smoking freebase (volatilized cocaine because of the lower boiling point) acts in seconds and results in an intense high lasting several minutes The intensity of the reaction is related to the marked lipid solubility of the freebase.

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