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Finalize revised report out Presentation: Organization Charts Coordinate logistics: Where Break out into groups to bulid Financial impacts and when BCC model Risks/mitigators and Invite participants and send Build new organization based interdependencies out activity survey on BCC model Execution timeline Determine # and sequence Deliver kickoff presentation of workouts based on ODA and review inputs Compile activity survey results Validate current organizational charts Obtain SVP or BU leader strategy presentation Define breakout groups and facilitators Build workout kickoff presentation Finalize new organizational charts and validate to existing organizational charts Validate all calculatioins Send final presentatioin to SVP or BU leader for review Identify project team leader and team for execution

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Human Resources Educational Services Support Services Product Marketing Product Engineering Value Chain CGO receives input from all links in the product value chain, as well as from the international units that distribute those products. Regional or Country Unit Management

A government-established organization was partly owned by its major customers. De ning the project who was a particularly useful starting point because the risk arising from the built-in con ict of interest inherent in the ownership/customer structure was identi ed formally for the organization s board of directors by a third party. Steps were taken to resolve the position, and the subsequent risk management process clearly allocated signi cant particular risks to speci c customers/shareholders.

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Over the past 50 years, evidence has accumulated about the clinical signi cance of marked individual differences in metabolism of drugs and in responses to drugs at the sites of therapeutic and adverse actions. The pioneers Kalow and Lehman identi ed speci c inherited traits that produced these marked differences in people who were entirely normal unless challenged with the particular drugs (Motulsky, 1957; Kalow, 1962). This new area of investigation was named pharmacogenetics by Vogel (1959). That term has powerful meaning today, generally referring to the actions of particular, individual genes or a few speci c interacting genes on drug response or adverse drug reaction. Pharmacogenetics is a subclass of the eld eco-genetics, with drugs being one of the many environmental agents interacting with genetic (and nongenetic) variation in the host individual of various exposed populations (Omenn and Motulsky, 1978; Eaton et al., 1999). Eco-genetics, in turn, is a signi cant part of public health genetics (Khoury et al., 2000; Omenn, 2000a). The newer term pharmacogenomics should be reserved, we believe, for genomic analyses employing the powerful tools of modern molecular biology: comparative genome hybridization for ampli cation of gene copy number, gene expression microarray analysis of levels of hundreds or thousands of messenger RNAs, and proteomic analysis of the level of expression of very large numbers of proteins. These analyses aim to detect evidence of variation in response to pharmaceutical action and in host factors in uencing the absorption, distribution, metabolism, and excretion (ADME) of those chemical agents. Originally, these methods identi ed mostly spots of unknown function; now more mRNAs and proteins are identi ed with particular classes of genes or proteins and their known or likely functions. It is possible that automation of the new techniques will so facilitate testing and

When developing a system, it is very dif cult for developers to remove themselves from the process of building software to see how a user would actually interact with the software. Therefore, the best way to get feedback about a user interface is to show potential users the interface prototypes and evaluate their responses. For interfaces with few screens, it may only be necessary to give a user some paper prototype sketches of the screens. For large systems with many screens, it is better to give the user an interface prototype that they can click through to see how the system works. The user should interact with the interface without prompting from the developers, but the developers should ask the user questions as she uses the prototype. Observing the user will help to determine interface effectiveness. Additionally, the user should be able to document her experience as she uses the program and should ll out a questionnaire when she is nished using

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