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compiled in such databases is protected under trade secret law Companies engaging in pharmacogenomics research utilize databases of their own creation or purchase licenses or subscriptions for access to database information services of genomics companies Through subscriber agreements, under which information accessed is kept con dential and used only for agreedupon research purposes, companies trade secrets in proprietary databases are effectively maintained Although a signi cant portion of the information contained in a genomics database may not be appropriate subject matter for patent, the collection, compilation, and organization of database content and tools useful in using it are valuable for biotechnology and pharmacogenomic research and protectable as trade secrets Comprehensive genomics databases and the proprietary software tools used for viewing, browsing, and analyzing data mined from them greatly hasten pharmacogenomic research and development.

Genomics companies use and sell information services that provide raw genomic sequence information, gene expression data, protein composition and structure, and data on genetic variation and gene function, as well as proprietary software and computer technology to make ef cient research use of the information Database information services are indispensable in facilitating and expediting development of pharmacogenomic therapies and products by providing some of the raw starting materials and reference points necessary for ef cient development Another key element in pharmacogenomic development often protected under trade secret is the technology platform, a core of integrated technologies used to drive innovation Various integrated platforms of biochips, microarrays, imaging and robotics equipment, software, and high-powered computers are used for high-throughput screening, sequencing, genotyping, haplotyping, expression and transcription pro ling, and a host of other analyses.

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Such sophisticated combinations of technology constitute valuable methodologies for pharmacogenomic development, and protection against their misappropriation is important to the platform owners vying for rights to patentable developments stemming from their use Companies may use proprietary technology platforms for their own pharmacogenomic development or license use of the platforms to other developers through various commercial arrangements License agreements for the use of proprietary platforms provide for con dentiality, shielding integrated systems comprised of component technologies not otherwise protected under patent and derived from and utilized with trade secret know-how from disclosure that would pierce trade secret protection Understanding that there is more to the protective intellectual property regime than patents is critical to a full appreciation of the nature and effect of commercial dealings in pharmacogenomics.

maximally -irreducible, meaning that for any other positive - nite measure on (H, ), , it is necessarily true that > . See Meyn and Tweedie (1993, pp. 88 89) for some additional but not critical details. 5.3.2.2 Closed and Absorbing Sets We say that a nonempty set A is obtainable from the state for the Markov chain de ned at time n by the kernel K n if K n ( , A) > 0 for some n 1, and unobtainable if K n ( , A) = 0 for all n 1. (5.4) (5.3)

Licensing of both trade secret databases and technology platforms, in addition to licensing of patented technology, forms the cornerstone of the commercial arrangements that drive this nascent industry..

8 7 6 5 AR, dB 4 3 2 1 0 19.5 Patch + meander polarizer Patch + strip polarizer Meander polarizer d = 0.5 cm

(14.44)

The estimated m3w (skewness) has a sampling distribution with high variance due to the third power of deviations from the mean needed in (5.2.4). Now the (possibly negative) skewness measure is de ned by scaling with standard deviation as Sk = m3w . 3 sdn

Figure 15.1. Refinement of a TSPN: first level of specification of the temporal behavior of a task (a); refinement of the first level in the form of a sequence of tasks (b); refinement of a task of the second level in the form of a parallel composition carried out using the operator of synchronization of the type strong-or (c)

[1] R F Harrington, in Time Harmonic Electromagnetic Fields, McGraw-Hill, New York, 1961, Microwave Networks, 8 [2] A K Bhattacharyya, Floquet-Modal-Based Analysis for Mutual Coupling Between Elements in an Array Environment, IEE Proc, Vol MAP-144, No 6, pp 491 497, Dec 1997 [3] D M Pozar, Input Impedance and Mutual Coupling of Rectangular Microstrip Antennas, IEEE Trans, Vol AP-30, pp 1191 11196, 1982 [4] A K Bhattacharyya, in Electromagnetic Fields in Multilayered Structures: Theory and Applications, Artech House, Norwood, 1994, pp 161 164 [5] A Ishimaru, R J Coe, G E Miller, and W P Green, Finite Periodic Structure Approach to Large Scanning Array Problems, IEEE Trans, Vol AP-33, No 11, pp 1213 1220, Nov 1985 [6] A K Skrivervik and J R Mosig, Finite Phased Array of Microstrip Patch Antennas, IEEE Trans, Vol AP-40, No 5, pp 579 582, May 1992 [7] A K.

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