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adrenal enzyme inhibitors such as ketoconazole, metapyrone, or aminoglutethimide The rate of cure for pituitary microadenoma by transsphenoidal surgery approaches 80 percent, although operative complications CSF leakage, transient diabetes insipidus, visual abnormalities, meningitis occur in as many as 10 percent of patients In about 20 percent of patients, removal of the tumor is incomplete and symptoms persist or recur In such circumstances reoperation is often undertaken, with total excision of the gland and a consequent requirement for extensive hormone replacement in many cases As an alternative, radiotherapy may be used after failed surgery If there is an urgent need to suppress the effects of hypercortisolism, bilateral adrenalectomy is effective but has obvious limitations Depending on the functional status of the pituitary after any mode of successful treatment, replacement therapy may be needed for a variable period.

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volume was up or down for the day It s almost an early form of the NYSE TICK data, explains Richard Dickson, Lowry s senior market strategist and market commentator We are counting points gained or lost for all the stocks on the exchange each day The difference is that it s done on a cumulative basis and not tick by tick If you had to summarize the trading philosophy of Lowry, it follows the trend A trend in motion tends to stay in motion until you see something that says it s going to reverse, Dickson says We don t try to predict when it is going to stop Lowry constantly analyzes the various stages of the trend carefully for any signs it could stop, also studying historical and current market conditions.

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In March 2009, Lowry got a 96 Buying Power Index (BPI) reading at the bear market bottom, one of the lowest readings ever recorded Buying power got so low we wondered if it was going to drop below zero, Dickson jests At first, they questioned whether the numbers had been warped by hedge funds exiting the market After analyzing the data, Lowry concluded that the evidence favored the bull side They put out an intermediate buy alert in August 2009, which turned out to be correct, although not the precise bottom If there is a secret to using indicators, Dickson says it s to know their nuances: Not every indicator works all the time You have to understand when it works and when it doesn t.

For nonlinearboundary-value problems,linear interpolationor extrapolation through two solutionpoints will not necessarily result in an accurate estimateof the requiredboundary condition to attain an exact solution.An alternative to perform threeapplications is ofthe shooting method and use a quadratic interpolating polynomial to estimatethe proper boundarycondition. However,it is unlikely that such an approachwould yield theexact answer,and additionaliterationswould be necessary home in on the solution. to Another approach a nonlinearprobleminvolvesrecasting as a rootsproblem. for it Recall that the generalgoal of a rootsproblemis to find the value of r that makesthefunction how the shooting method f (x) :0. Now, let us usethe heatedrod problemto understand can be recastin this form. First, recognizethat the solution of the pair of differentialequations alsoa "funcis tion" in the sense that we guessa conditionat the left-handend of the rod zn, andtheintegration yields a predictionof the temperature the right-hand end 76.Thus, we canthink at of the integrationas

The worst thing you can do is to be on a search for that secret ingredient that will tell you what the market will do You end up like a dog chasing its tail How does he know when his indicators stop working That s easy, he quips You re losing money He is sometimes surprised that indicators he has depended on in the past suddenly stop working Indicators stop working when the character of the market stops working, Dickson explains A classic example is the odd lot trading indicator, which used to be a sentiment indicator The options market and electronic exchanges made the odd lot indicator obsolete..

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