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When you enter data into a text file using the WriteLine() method, it automatically enters a line break, so when you use the ReadLine(), it knows what text is considered to be a separate line. Text entered in other ways marks the end of the line with either of the other two acceptable markers that ReadLine() can find. The following web site example reads the Pauper Database (pauperDataBase.txt), and it shows how you can retrieve and display the records from any text file:

For example, medulloblastomas that express genes indicative of cerebellar differentiation are associated with longer survival than those expressing genes related to cell division (Pomeroy et al) Furthermore, as alluded to earlier, in about 50 percent of gliomas there is an overexpression or a mutant form of epidermal growth factor (EGF) and of transforming growth factor alpha (TGF- ), suggesting a role for these in the progression of certain tumor types Other trophic factors are overexpressed in yet other brain neoplasms and perhaps contribute to their morphology and growth pattern; for example, VEGF is found in extremely high concentrations in meningiomas, which are highly vascular by nature These ndings, taken together, suggest an autocrine stimulation of growth by these factors and possibly an interaction with some of the aforementioned gene defects.

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The liver is the main locus of drug metabolism, and the kidney is the method of elimination of the metabolites All the barbiturates are similar pharmacologically and differ only in the speed of onset and duration of their action The clinical problems posed by the barbiturates are different, however, depending on whether the intoxication is acute or chronic Acute Barbiturate Intoxication This results from the ingestion of large amounts of the drug, either accidentally or with suicidal intent The latter is most frequently the act of a depressed person The hysteric or sociopath may take an overdose as a suicidal gesture and become seriously intoxicated because of miscalculation or ignorance of the toxic dosage Often the drug is taken while the individual is inebriated a dangerous situation, since alcohol and barbiturate have an additive effect.

The symptoms and signs vary with the type and amount of drug as well as with the length of time that has elapsed since it was ingested Pentobarbital and secobarbital produce their effects quickly, and recovery is relatively rapid Phenobarbital induces coma more slowly, and its effects tend to be prolonged In the case of long-acting barbiturates, such as phenobarbital and barbital, the hypnotic-sedative effect lasts 6 h or more after an average oral dose; with the intermediate-acting drugs such as amobarbital, 3 to 6 h; and with the short-acting drugs, secobarbital and pentobarbital, less than 3 h Most fatalities follow the ingestion of secobarbital, amobarbital, or pentobarbital The ingestion by adults of more than 30 g of these drugs at one time will prove fatal unless intensive treatment is applied promptly The potentially fatal dose of phenobarbital is 6 to 10 g.

However, having emphasized molecular and chromosomal changes, it is not yet clear if any of them is truly causative (the currently favored hypothesis) or if they simply re ect an aberrant genetic process that accompanies the dedifferentiation of tumor growth and progression On the basis of this new molecular information, our views of the pathogenesis of neoplasia are being cast along new lines Some of the speci cs of these new data are presented in the following discussions of particular tumor types A more extensive review can be found in the article by Osborne and colleagues, including the heterogeneity of ndings that suggests polygenic changes in most gliomas..

The lowest plasma concentration associated with lethal overdosage of phenobarbital or barbital has been approximately 60 mg/mL and that of amobarbital and pentobarbital, 10 mg/mL In regard to prognosis and treatment, it is useful to recognize three grades of severity of acute barbiturate intoxication Mild intoxication follows the ingestion of approximately 03 g pentobarbital (the hypnotic dose in an unhabituated patient is 100 mg) or its equivalent The patient is drowsy or asleep, although readily roused if called or shaken The symptoms resemble those of alcohol intoxication The patient thinks slowly, and there may be mild disorientation, lability of mood, impairment of judgment, slurred speech, drunken gait, and nystagmus Moderate intoxication follows the ingestion of 5 to 10 times the oral hypnotic dose The patient is stuporous, tendon re exes are usually depressed or absent, and respirations are slow but not shallow.

TABLE 4-21

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