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be much worse Consider an idealized software project that will require ten separate subroutines to be developed in parallel The boss asks the programming manager of the rst subroutine how long development will take I m confident it will take somewhere between three and nine months replies the programming manager Give me a number, says the boss I have to tell the chief operating officer when we ll be operational! Well, says the programming manager, on average, programs like this take about six months Use that if you need a single number For simplicity of argument, assume that the boss has similar conversations with each of the nine remaining programming managers The durations of all the subroutines are uncertain and independent, and they are expected to range between three and nine months with an average of six months.

(6) views self as socially inept, personality unappealing, or inferior to others (1) avoids occupational activities that involve significant interpersonal contact, because of fears of criticism, disapproval, or rejection (4) is preoccupied with being criticized or rejected in social situations (2) is unwilling to get involved with people unless certain of being liked (3) shows restraint within intimate relationships because of the fear of being shamed or ridiculed (5) is inhibited in interpersonal situations because of feelings of inadequacy (7) is unusually reluctant to take personal risks or to engage in any new activities because they may prove embarrassing

tance for a matching network can be gured out simultaneously and without dif culty. Usually, not only z, y, and but also other related parameters are marked in a Smith chart. They are:

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microscope that can make two-dimensional surface distribution measurements by X-ray scanning is shown in Figure 3.2.3(a). A small-sized instrument, which can be used in a normal laboratory is realized by a combination of single capillaries and a low power X-ray generator of 50 W. An X-ray microbeam is emitted vertically through a single capillary and reaches the sample. The sample is placed on an X-Y stage and can thus be scanned in two dimensions. Both transmitted X-rays and uorescent X-rays are detected, and a two-dimensional image is obtained by computing signals from these detectors.

pharmacogenomics entities requiring access to outside resources to effectuate the best use of their own shares of the eld s collective intellectual property. This chapter examines the forms of legal protection available to those in the business of pharmacogenomics to protect their intellectual property and how such protection is applied to discover more effective drugs, advance the state of the medical art, and create value for shareholders. Furthermore, this chapter explores the types of business models and commercial arrangements including licensing and collaborative partnerships used by entities in the eld to optimize pharmacogenomic end points and therapies. Only by understanding the methods of protection for such important intellectual property as genes, expressed sequence tags (ESTs), single-nucleotide polymorphisms (SNPs), genomic databases, and technology platforms, as well as the spectrum of relationships built around such property to capture its value, can the commercial aspects of pharmacogenomics be fully understood. Although analysis of the intellectual property protection and interplay among the commercial entities controlling those protected assets is indispensable in gaining an appreciation of the driving forces in pharmacogenomics business, the scope of this chapter does not reach many other important aspects of the eld. Notably, the multitude of regulatory, social, and ethical considerations that must be addressed by the industry are not analyzed in this discussion. Such important topics, however, are treated elsewhere in this book. This chapter provides a comprehensive overview of the most important intellectual property and commercial aspects of pharmacogenomics, providing the reader with a framework for the industry from a business standpoint.

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