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, 2001; Muhle et al, 2004); the polygenetic basis of ASD may explain the variations across the ASD In addition, others have identi ed gene mutations that form nonsyndromic or syndromic variants Finally, some genes have been identi ed as vulnerability genes with potential increased risk, but they are not associated directly with ASD itself (Persico & Bourgeron, 2006) A person has a 10- to 20-fold increase compared to the general population of developing autism if he or she has a sibling with autism, and a number of studies have demonstrated a family history of social and language de cits in persons with autism In all, a number of proteins involved in neurodevelopment and synaptic function have been identi ed; to some extent, these have been linked with one of the genetic pathways or gene-environment interactions.

All this information about search engines has one purpose to show you how they work, so that you can put them to work for you. Throughout this book, you ll find various strategies for optimizing your web site so it appears high in search engine rankings when relevant searches are performed. But this requires that you know how to put search engines to work for you.

The cursor-configuration properties, shown in Table 34-9, are used to control cursor behavior in SQL Server.

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In particular, there are X-linked disorders (Rett, fragile X syndrome) where ASD is a secondary manifestation of the primary disorder; while Rett disorder is classi ed among the ASDs, 20% to 40% of individuals with fragile X also meet criteria for ASD The variations in genes and associated proteins further contributes to the heterogeneity of individuals with ASDs (Persico & Bourgeron, 2006) In some cases, it is not solely the genetic makeup that affects the manifestation of ASDs Further, the phenotypic expression of the disorder varies widely, even within monozygotic twins, suggesting a combination of genetic and environmental factors (Amaral, Schumann, & Nordahl, 2008) Autistic.

3: Hardware and Software Compatibility ............................................................... 89

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When dealing with ADO.NET data providers, the obvious starting point is the Connection object, which provides the basis for which all the other ADO.NET data provider objects acquire and maintain their connections with their associated data stores. If you are familiar with ADO Connection objects, you should be instantly familiar with the Connection objects implemented in ADO.NET. The Connection objects included by data providers each provide at least two constructor overrides. Listing 22-1 demonstrates connecting to databases in .NET using the ADO.NET Connection object. Listing 22-1: Connecting to .NET Databases with the ADO.NET SQLConnection Object

has dialed the MSISDN of MS, and the xed network uses MSISDN to set up a connection to a gateway MSC (GMSC) in the home PLMN. GMSC interrogates HLR and obtains the mobile station roaming number (MSRN), which is used to extend the connection to the MSC that is currently serving MS. In the gure, the latter part of the connection is made in the xed network. Some PLMNs have trunk groups between their MSCs. In that case, the connection from GMSC to MSC is made with PLMN trunks. In Fig. 19.8-2, the calling party is in country 1, the home PLMN of MS is in country 2, and the MS is currently visiting a PLMN in country 3. The calling party has dialed the country code of country 2, followed by MSISDN, and the call setup arrives at GMSC. GMSC interrogates HLR and obtains the country code of country 3 and the MSRN. The xed network uses these parameters to route the call to the MSC that is serving MS. The resulting connection is not always an economic one. Let us consider the case that countries 1, 2, and 3 are Belgium, Argentina, and France, respectively. A direct connection from Belgium to France would be more economical than a connection via Argentina. Automatic rerouting (Section 1.3.4) can alleviate this problem in some instances. Suppose that in Fig. 19.8-3 the trunks between international switching centers ISC-A and ISC-B, and between ISC-B and GMSC, have SS7 signaling, that ISC-A has rerouting capability, and that GMSC can determine from the calling party number received from ISC-A and the MSRN received from HLR that the originating and terminating countries are Belgium and France. It then sends a Backward Unsuccessful message (BUM) to ISC-B. The message includes the country

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